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Electropharmacogram in the rat: Four semi-microelectrodes are fixed to skull and allow quantitative-topological EEG with specified receptor determination after drug application. Electropharmacograms can be compared to the existing Neo-Cateem database to 200 different drugs in different dosages – acting on acetylcholine, norepinephrine, serotonine, dopamine, glutamate and GABA neurotransmitters. New data is screened for similarities among frequency segments and generates a list showing corelation index with statistical probability. Quantitative EEG is therefore useful for
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The Neo-Cateem database consist of 30 000 hours of recording of more than 200 chemicals and drugs with at least 3 dosages, including:
The image to the right shows time dependent effects of scopolamine at 0,5 mg/kg administered i.p. to the rat. |
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